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Modelling pulsatile profiles in NONMEM

A modellers challenge: getting data in front of you that don’t seem to fit any of the standard effect models and PKPD relationships. Especially in endocrinology, hormonal profiles are rarely …

Building your first PBPK model:the basics

In previous posts we referred exclusively to modelling using the top-down, population approach. However, in recent years, physiology-based, bottom-up approaches are getting more attention from both industry and regulators. Population …