$PROBLEM 1 Compartment - Linear elimination - Proportional residual error

$INPUT ID TIME AMT EVID DV CMT MDV

$DATA VPC.Dataset.2018-06-24.csv IGNORE=I 


$SUB ADVAN13 TOL=9

$MODEL
COMP=(DEPOT)
COMP=(CENTRAL)

$PK
ka = THETA(1)*EXP(ETA(1))

V1 = THETA(2)*EXP(ETA(2))

CL = THETA(3)*EXP(ETA(3))

k10 = CL/V1

S2 = V1

$DES
DADT(1)= -ka*A(1)

DADT(2)= ka*A(1) - k10*A(2)


$ERROR
IPRE = 0.00001
IF(F.GT.0) IPRE = F
Y = IPRE * (1 + EPS(1)) + EPS(2)

$THETA
(0,0.673) ; Absorption rate constant
(0,14.3) ; Volume of distribution - central compartment
(0,3.05) ; Clearance


$OMEGA
0.1
0.0958
0.0961


$SIGMA
0.106 ; Proportional
0 FIX ; Additive

$SIM (12345) ONLYSIMULATION SUBPROBLEMS=500

$TABLE ID TIME DV CMT IPRE CPREDI CRESI CWRESI NOPRINT ONEHEADER FILE = SDTABSim1
$TABLE ID ETAS(1:LAST) NOPRINT ONEHEADER FIRSTONLY FILE = PATABSim1