$PROBLEM 1 Compartment - Linear elimination - Proportional residual error

$INPUT ID TIME AMT DOSE EVID DV CMT MDV WGT 

$DATA Estimation.Dataset.LowRSE.2019-01-22.csv IGNORE=I 


$SUB ADVAN13 TOL=9

$MODEL
COMP=(DEPOT)
COMP=(CENTRAL)

$PK
ka = THETA(1)

V1 = THETA(2)*EXP(ETA(1))


TVCL = THETA(3)
CL =TVCL*EXP(ETA(2))


k10 = CL/V1

S2 = V1

$DES
DADT(1)= -ka*A(1)

DADT(2)= ka*A(1) - k10*A(2)


$ERROR
IPRE = 0.00001
IF(F.GT.0) IPRE = F
Y = IPRE * (1 + EPS(1))

$THETA
(0,1) ; Absorption rate constant
(0,15) ; Volume of distribution - central compartment
(0,8) ; Clearance slope


$OMEGA
0.1
0.1


$SIGMA
0.1 ; Proportional

$EST PRINT=5 MAX=9999 METHOD=1 NSIG=3 SIGL=6 INTERACTION POSTHOC NOABORT MSFO=mfi
$COV MATRIX=R PRINT=E

$TABLE ID TIME AMT EVID DV CMT MDV IPRE PRED DOSE CPREDI CRESI CWRESI NOPRINT ONEHEADER FILE = SDTABModel2
$TABLE ID ETAS(1:LAST) NOPRINT ONEHEADER FIRSTONLY FILE = PATABModel2