Simulating your pharmacometric model with parameter uncertainty in R
How certain are we about the parameters that we estimate in our population model? Is that volume of distribution that NONMEM gave us really 10 liters with a clearance of …
Creating a simple pharmacometric Shiny application with mrgsolve in R – Part 2
Shiny applications are a great way to show your complicated models in an interactive way. In recent years, many different examples have been published online showcasing a wide range of …
Creating a simple pharmacometric Shiny application with mrgsolve in R – Part 1
This two part series will show you how to create a simple pharmacometric Shiny application using the mrgsolve package in R. I think that Shiny applications are the most promising way …
Getting your NONMEM dataset to work – DATA ERROR summary
Getting your dataset in the right format to work with NONMEM can be a terrible job. Getting all your observations, doses, dosing times, etc. from different Excel sheets collected in …
A step-by-step guide to prediction corrected visual predictive checks (VPC) of NONMEM models
Introduction Back in 2011, a very nice paper introducing the prediction corrected VPC was published by Bergstrand et al, titled: “Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models” In …
Execute NONMEM models via the right-click menu (with user specified commands)
Wouldn’t it be nice to have this option when you click on a model file: It can be quite a hassle to start the execution of your NONMEM models. Luckily, …
Visualizing the NONMEM model fit in R using mrgsolve – with code
It is difficult to grasp what non-linear mixed effects modelling software is actually doing when you start a run. Furthermore, the iteration prints that you see in the console (when …
A step-by-step guide to percentile visual predictive checks (VPC) of NONMEM models
This blog is an extension on the previously discussed scatter VPC. A percentile visual predictive check (VPC) can be used to compare the distribution of the observations with the simulated distributions …
Population pharmacokinetic model development in NONMEM workflow
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Running NONMEM models and R-scripts from batch (.bat) files
When you start to use NONMEM, the first thing that you notice is that there is no graphical user interface (GUI) that comes with it. This can be a shock …