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Tag: Visual predictive check

VPC Tutorial

A step-by-step guide to prediction corrected visual predictive checks (VPC) of NONMEM models

Introduction Back in 2011, a very nice paper introducing the prediction corrected VPC was published by Bergstrand et al, titled: “Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models” In …

VPC Tutorial

A step-by-step guide to percentile visual predictive checks (VPC) of NONMEM models

This blog is an extension on the previously discussed scatter VPC. A percentile visual predictive check (VPC) can be used to compare the distribution of the observations with the simulated distributions …

VPC Tutorial

A step-by-step guide to confidence interval visual predictive checks (VPC) of NONMEM models

Last time, we focused on the percentile VPC, which was already quite an improvement to the scatter VPC but one may wonder when looking at a percentile VPC, how certain …

VPC Tutorial

A step-by-step guide to scatter visual predictive checks (VPC) of NONMEM models

There are many different ways to evaluate model performance, and sometimes it seems that there are even more ways to use a visual predictive check (VPC) for your population PK …

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