With the introduction of ChatGPT I was interested to learn how ChatGPT in pharmacometrics might be applied and how this will impact my code writing tasks, especially for doing pharmacokinetic …
Shiny applications are commonly used as a data dashboard, to automate a (data science) workflow, or to easily build a minimum viable product. Shiny is a great tool if you …
Pharmacometrics is a rapidly growing field that combines pharmacology, mathematics, and statistics to optimize drug development and dosing. It is the science of quantifying drug effects in patients and developing …
A range of new shiny applications have been published on this website to visualise pharmacokinetic profiles over time and better understand the use of population models. All applications can be …
This page provides an overview of the abbreviations and terminology commonly used in population PK/PD articles.
The information in the covariance matrix Everyone that has worked for longer than a day with NONMEM has a high probability of encountering error messages mentioning the covariance matrix (nonpositive …
The development of population PK (and PD) models enable the use of individual Bayesian dose optimization. One could use the included covariates to derive the dose of an individual but …
Acknowledgments The idea for this post was based upon the research by Dr. Lloyd Bridge, presented at the British Pharmacological Society meeting December 2018. and published in October 2020 in …
The correct reporting of pharmacokinetic data can provide a tremendous amount of information on the clinical pharmacological characteristics of a drug. Small studies with a limited number of plasma samples …
Introduction We are not all the same. We know that there is variability originating from physiological differences in the pharmacokinetic and pharmacodynamic (PK/PD) processes between individuals in a population, also …
