Abbreviations and Terminology Used in Population Pharmacokinetics/Pharmacodynamic Models and in Pharmacometrics
This page provides an overview of the abbreviations and terminology commonly used in population PK/PD articles.
Publishing the covariance matrix of population models. Why not?
The information in the covariance matrix Everyone that has worked for longer than a day with NONMEM has a high probability of encountering error messages mentioning the covariance matrix (nonpositive …
Visualizing the NONMEM model fit in R using mrgsolve – with code
It is difficult to grasp what non-linear mixed effects modelling software is actually doing when you start a run. Furthermore, the iteration prints that you see in the console (when …
A step-by-step guide to percentile visual predictive checks (VPC) of NONMEM models
This blog is an extension on the previously discussed scatter VPC. A percentile visual predictive check (VPC) can be used to compare the distribution of the observations with the simulated distributions …
A step-by-step guide to confidence interval visual predictive checks (VPC) of NONMEM models
Last time, we focused on the percentile VPC, which was already quite an improvement to the scatter VPC but one may wonder when looking at a percentile VPC, how certain …
A step-by-step guide to scatter visual predictive checks (VPC) of NONMEM models
There are many different ways to evaluate model performance, and sometimes it seems that there are even more ways to use a visual predictive check (VPC) for your population PK …
A step-by-step guide to goodness of fit figures of NONMEM models in R using ggplot2
Model evaluation is a critical step in model development. A very good paper on how to evaluate continuous data pharmacometric models was published by Nguyen et al. in 2017, this …